Medical disclaimer: This tool is for general educational information only. It is not a substitute for medical or pharmacist advice, and it does not cover every possible interaction or every medication on the market. It only checks the roughly 35 supplement-drug combinations documented on this page, sourced from NIH and FDA resources. Always consult your doctor or pharmacist before starting, stopping, or combining any supplement while on prescription medication, especially blood thinners, diabetes medication, antidepressants, thyroid medication, or blood pressure medication.

Pick one prescription medication (or drug class) and one supplement or herbal ingredient below. If we have a documented interaction on file for that exact combination, sourced from the NIH Office of Dietary Supplements, NIH National Center for Complementary and Integrative Health (NCCIH), MedlinePlus, or the FDA, we will show you the documented mechanism and link to the source. If we do not have a documented interaction on file, we will tell you that too, but that is not the same as a guarantee that the combination is safe. This tool never says a combination is “safe,” only whether a known interaction is documented in our sources.

Looking for supplement dosage ranges instead? Try our free Ingredient Dose Checker tool, or browse the full Ingredient Guides library.

How this tool works

Every entry in this checker’s data set is drawn directly from an NIH Office of Dietary Supplements fact sheet, an NIH National Center for Complementary and Integrative Health (NCCIH) resource, a MedlinePlus page, or an FDA safety communication. If a commonly claimed supplement-drug interaction could not be traced to one of those sources, it was left out of this tool entirely rather than included with a hedge. That means this tool is intentionally incomplete. It covers roughly 35 of the most commonly documented and highest-consequence combinations, not every medication or every supplement that exists.

A “no documented interaction found” result means exactly that: our sources do not document a specific interaction for that exact pair. It does not mean the combination has been studied and cleared, and it is never a substitute for telling your doctor or pharmacist about every supplement you take.

Full reference table of documented interactions

This is the complete list this tool checks against, for reference or for scanning quickly without using the dropdowns above.

Sources

    This tool does not diagnose, treat, or prevent any condition, and it does not account for your age, other health conditions, kidney or liver function, pregnancy or breastfeeding status, or the full list of medications and supplements you take. A documented interaction shown above means that combination carries a known, sourced risk to discuss with your doctor or pharmacist, not an instruction to stop or change any medication yourself. Always talk to a doctor or pharmacist before starting, stopping, or combining any supplement alongside prescription medication.