Best Anti-Aging Supplement for Men: Energy and Muscle Support
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Best Anti-Aging Supplement for Men: Energy and Muscle Support

ByRovuno Reviews Team
Reviewed by the RovunoReviews Research Team · Reviewed against our Review Methodology · Updated September 2026

Medical disclaimer: This article is for informational purposes only and is not medical advice. Individual results vary. Consult a healthcare professional before starting any supplement, especially if you take other medications or have a liver, kidney, heart, or thyroid condition.

For a lot of men, the first noticeable sign of aging is not gray hair. It is a gradual dip in energy and a harder time maintaining muscle that used to come easily. Both changes are tied to real, well-documented biological shifts, including a natural decline in mitochondrial function and, for many men, a gradual decrease in testosterone starting around their 30s.

Quick Answer

NMN and related compounds are studied for their association with supporting cellular energy production, while adequate protein intake and resistance training remain the two most impactful levers for maintaining muscle with age. Supplements support the biology behind energy and muscle maintenance. They do not replace training or reverse aging itself.

Why Energy and Muscle Both Change With Age

Mitochondria, the energy-producing structures inside your cells, become somewhat less efficient with age, which researchers studying cellular aging have connected to some of the energy decline many men notice starting in their 40s and 50s. Separately, age-related muscle loss (sometimes called sarcopenia when significant) is driven by a combination of hormonal shifts and, importantly, reduced physical activity, which means it is not purely inevitable.

What Can Support Cellular Energy and Muscle Maintenance

  • NMN and nicotinamide riboside: Precursors to NAD+, a molecule involved in cellular energy production, currently studied for their association with supporting cellular energy metabolism, though long-term human research is still developing.
  • Resveratrol: Often paired with NMN in anti-aging formulas, studied for its association with cellular health markers, with evidence still primarily at an early research stage.
  • Adequate protein intake: The single most impactful nutritional lever for maintaining muscle mass with age, and many men’s needs increase, not decrease, as they get older.
  • Resistance training: Not a supplement, but by far the most effective intervention for age-related muscle maintenance, and one no supplement replaces.

What to Look For

If considering NMN, look for a reputable third-party tested source and go in with realistic expectations. Current human research on NMN is early-stage, and no supplement in this category is proven to reverse aging or extend lifespan as established fact. Prioritize protein intake and resistance training first, and treat cellular energy supplements as a genuine complement, not a replacement.

Bottom Line

Energy and muscle changes with age are real and tied to identifiable biological shifts, including mitochondrial efficiency and hormonal changes. NMN and resveratrol are reasonable, if still early-stage, additions to support cellular energy, while protein intake and resistance training remain the most proven levers for muscle maintenance.

Frequently Asked Questions

Q: Is NMN proven to increase energy in humans?
A: Human research on NMN is still developing, and while some studies show promising cellular markers, it is not established as a guaranteed energy booster the way regular exercise and sleep are.

Q: Can supplements alone maintain muscle mass as I age?
A: No. Resistance training and adequate protein intake are the primary drivers of age-related muscle maintenance, and supplements work best as a complement to both, not a substitute.

Q: Is NMN currently regulated the same as other supplements?
A: NMN’s regulatory status has shifted over recent years, and it is worth checking current guidance, since its availability as a dietary supplement has been affected by ongoing regulatory review.

Q: How much protein do men need as they age?
A: Many nutrition researchers suggest older men need more protein than younger adults to maintain muscle, often above the general RDA, though individual needs vary and are worth discussing with a doctor or dietitian.

Related Reading

Sources

These statements have not been evaluated by the Food and Drug Administration. This content is not intended to diagnose, treat, cure, or prevent any disease and is not a substitute for advice from your doctor or pharmacist.